Heterologous prime–boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory syndrome coronavirus
Identifieur interne : 000957 ( Main/Exploration ); précédent : 000956; suivant : 000958Heterologous prime–boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory syndrome coronavirus
Auteurs : Seo-Yeon Jung [Corée du Sud] ; Kyung Won Kang [Corée du Sud] ; Eun-Young Lee [Corée du Sud] ; Dong-Won Seo [Corée du Sud] ; Hong-Lim Kim [Corée du Sud] ; Hak Kim [Corée du Sud] ; Taewoo Kwon [Corée du Sud] ; Hye-Lim Park [Corée du Sud] ; Hun Kim [Corée du Sud] ; Sang-Myeong Lee [Corée du Sud] ; Jae-Hwan Nam [Corée du Sud]Source :
- Vaccine [ 0264-410X ] ; 2018.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (), Adjuvants immunologiques (administration et posologie), Adénovirus humains (génétique), Adénovirus humains (immunologie), Alun (administration et posologie), Animaux, Anticorps antiviraux (biosynthèse), Anticorps neutralisants (biosynthèse), Calendrier vaccinal, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Femelle, Glycoprotéine de spicule des coronavirus (administration et posologie), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Humains, Immunoglobuline G (biosynthèse), Immunogénicité des vaccins, Infections à coronavirus (), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Lymphocytes auxiliaires Th1 (), Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th1 (virologie), Lymphocytes auxiliaires Th2 (), Lymphocytes auxiliaires Th2 (immunologie), Lymphocytes auxiliaires Th2 (virologie), Nanoparticules (), Nanoparticules (administration et posologie), Rappel de vaccin (), Souris, Souris de lignée BALB C, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie).
- MESH :
- administration et posologie : Adjuvants immunologiques, Alun, Glycoprotéine de spicule des coronavirus, Nanoparticules, Vaccins antiviraux.
- biosynthèse : Anticorps antiviraux, Anticorps neutralisants, Immunoglobuline G.
- génétique : Adénovirus humains, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux.
- immunologie : Adénovirus humains, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Vaccins antiviraux.
- virologie : Infections à coronavirus, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2.
- Activation des lymphocytes, Animaux, Calendrier vaccinal, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Humains, Immunogénicité des vaccins, Infections à coronavirus, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Nanoparticules, Rappel de vaccin, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Adenoviruses, Human (genetics), Adenoviruses, Human (immunology), Adjuvants, Immunologic (administration & dosage), Alum Compounds (administration & dosage), Animals, Antibodies, Neutralizing (biosynthesis), Antibodies, Viral (biosynthesis), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Coronavirus Infections (virology), Female, Humans, Immunization Schedule, Immunization, Secondary (methods), Immunogenicity, Vaccine, Immunoglobulin G (biosynthesis), Lymphocyte Activation (drug effects), Mice, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Nanoparticles (administration & dosage), Nanoparticles (chemistry), Spike Glycoprotein, Coronavirus (administration & dosage), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Th1 Cells (drug effects), Th1 Cells (immunology), Th1 Cells (virology), Th2 Cells (drug effects), Th2 Cells (immunology), Th2 Cells (virology), Viral Vaccines (administration & dosage), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Alum Compounds, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- chemical , biosynthesis : Antibodies, Neutralizing, Antibodies, Viral, Immunoglobulin G.
- administration & dosage : Nanoparticles.
- chemistry : Nanoparticles.
- drug effects : Lymphocyte Activation, Middle East Respiratory Syndrome Coronavirus, Th1 Cells, Th2 Cells.
- genetics : Adenoviruses, Human, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- immunology : Adenoviruses, Human, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Th1 Cells, Th2 Cells, Viral Vaccines.
- methods : Immunization, Secondary.
- prevention & control : Coronavirus Infections.
- virology : Coronavirus Infections, Th1 Cells, Th2 Cells.
- Animals, Female, Humans, Immunization Schedule, Immunogenicity, Vaccine, Mice, Mice, Inbred BALB C.
Abstract
Immunization with MERS spike protein nanoparticles induced only Th2-biased response. Heterologous prime-boost immunization induced both Th1 and Th2-biased responses. Our vaccination strategy showed the protective effect against MERS-CoV.
Url:
DOI: 10.1016/j.vaccine.2018.04.082
PubMed: 29739720
PubMed Central: 7115429
Affiliations:
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Le document en format XML
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last="Kim">Hong-Lim Kim</name><affiliation wicri:level="1"><nlm:aff id="af015">Seoul St. Mary's Hospital, School of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul St. Mary's Hospital, School of Medicine, The Catholic University of Korea, Seoul 06591</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Hak" sort="Kim, Hak" uniqKey="Kim H" first="Hak" last="Kim">Hak Kim</name><affiliation wicri:level="1"><nlm:aff id="af020">Division of VAX R&D, Life Science Research Institute, SK Chemical, Seongnam 12771, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of VAX R&D, Life Science Research Institute, SK Chemical, Seongnam 12771</wicri:regionArea><wicri:noRegion>Seongnam 12771</wicri:noRegion></affiliation></author><author><name sortKey="Kwon, Taewoo" sort="Kwon, Taewoo" uniqKey="Kwon T" first="Taewoo" last="Kwon">Taewoo Kwon</name><affiliation wicri:level="1"><nlm:aff id="af020">Division of VAX R&D, Life Science Research Institute, SK Chemical, Seongnam 12771, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of VAX R&D, Life Science Research Institute, SK Chemical, Seongnam 12771</wicri:regionArea><wicri:noRegion>Seongnam 12771</wicri:noRegion></affiliation></author><author><name sortKey="Park, Hye Lim" sort="Park, Hye Lim" uniqKey="Park H" first="Hye-Lim" last="Park">Hye-Lim Park</name><affiliation wicri:level="1"><nlm:aff id="af005">Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biotechnology, The Catholic University of Korea, Bucheon 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570-752</wicri:regionArea><wicri:noRegion>Iksan 570-752</wicri:noRegion></affiliation></author><author><name sortKey="Nam, Jae Hwan" sort="Nam, Jae Hwan" uniqKey="Nam J" first="Jae-Hwan" last="Nam">Jae-Hwan Nam</name><affiliation wicri:level="1"><nlm:aff id="af005">Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biotechnology, The Catholic University of Korea, Bucheon 14662</wicri:regionArea><wicri:noRegion>Bucheon 14662</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviruses, Human (genetics)</term><term>Adenoviruses, Human (immunology)</term><term>Adjuvants, Immunologic (administration & dosage)</term><term>Alum Compounds (administration & dosage)</term><term>Animals</term><term>Antibodies, Neutralizing (biosynthesis)</term><term>Antibodies, Viral (biosynthesis)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (prevention & control)</term><term>Coronavirus Infections (virology)</term><term>Female</term><term>Humans</term><term>Immunization Schedule</term><term>Immunization, Secondary (methods)</term><term>Immunogenicity, Vaccine</term><term>Immunoglobulin G (biosynthesis)</term><term>Lymphocyte Activation (drug effects)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Nanoparticles (administration & dosage)</term><term>Nanoparticles (chemistry)</term><term>Spike Glycoprotein, Coronavirus (administration & dosage)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Th1 Cells (drug effects)</term><term>Th1 Cells (immunology)</term><term>Th1 Cells (virology)</term><term>Th2 Cells (drug effects)</term><term>Th2 Cells (immunology)</term><term>Th2 Cells (virology)</term><term>Viral Vaccines (administration & dosage)</term><term>Viral Vaccines (genetics)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes ()</term><term>Adjuvants immunologiques (administration et posologie)</term><term>Adénovirus humains (génétique)</term><term>Adénovirus humains (immunologie)</term><term>Alun (administration et posologie)</term><term>Animaux</term><term>Anticorps antiviraux (biosynthèse)</term><term>Anticorps neutralisants (biosynthèse)</term><term>Calendrier vaccinal</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Femelle</term><term>Glycoprotéine de spicule des coronavirus (administration et posologie)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Humains</term><term>Immunoglobuline G (biosynthèse)</term><term>Immunogénicité des vaccins</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Lymphocytes auxiliaires Th1 ()</term><term>Lymphocytes auxiliaires Th1 (immunologie)</term><term>Lymphocytes auxiliaires Th1 (virologie)</term><term>Lymphocytes auxiliaires Th2 ()</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Lymphocytes auxiliaires Th2 (virologie)</term><term>Nanoparticules ()</term><term>Nanoparticules 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coronavirus</term><term>Nanoparticules</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymphocyte Activation</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Th1 Cells</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviruses, Human</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénovirus humains</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Adénovirus humains</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Infections à coronavirus</term><term>Lymphocytes auxiliaires Th1</term><term>Lymphocytes auxiliaires Th2</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Adenoviruses, Human</term><term>Coronavirus Infections</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Spike Glycoprotein, Coronavirus</term><term>Th1 Cells</term><term>Th2 Cells</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Secondary</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Lymphocytes auxiliaires Th1</term><term>Lymphocytes auxiliaires Th2</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Th1 Cells</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Humans</term><term>Immunization Schedule</term><term>Immunogenicity, Vaccine</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Calendrier vaccinal</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Femelle</term><term>Humains</term><term>Immunogénicité des vaccins</term><term>Infections à coronavirus</term><term>Lymphocytes auxiliaires Th1</term><term>Lymphocytes auxiliaires Th2</term><term>Nanoparticules</term><term>Rappel de vaccin</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">Immunization with MERS spike protein nanoparticles induced only Th2-biased response.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">Heterologous prime-boost immunization induced both Th1 and Th2-biased responses.</p></list-item><list-item id="o0015"><label>•</label><p id="p9708">Our vaccination strategy showed the protective effect against MERS-CoV.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chan, J F W" uniqKey="Chan J">J.F.W. 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Varga</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Jung, Seo Yeon" sort="Jung, Seo Yeon" uniqKey="Jung S" first="Seo-Yeon" last="Jung">Seo-Yeon Jung</name></noRegion><name sortKey="Kang, Kyung Won" sort="Kang, Kyung Won" uniqKey="Kang K" first="Kyung Won" last="Kang">Kyung Won Kang</name><name sortKey="Kim, Hak" sort="Kim, Hak" uniqKey="Kim H" first="Hak" last="Kim">Hak Kim</name><name sortKey="Kim, Hong Lim" sort="Kim, Hong Lim" uniqKey="Kim H" first="Hong-Lim" last="Kim">Hong-Lim Kim</name><name sortKey="Kim, Hun" sort="Kim, Hun" uniqKey="Kim H" first="Hun" last="Kim">Hun Kim</name><name sortKey="Kwon, Taewoo" sort="Kwon, Taewoo" uniqKey="Kwon T" first="Taewoo" last="Kwon">Taewoo Kwon</name><name sortKey="Lee, Eun Young" sort="Lee, Eun Young" uniqKey="Lee E" first="Eun-Young" last="Lee">Eun-Young Lee</name><name sortKey="Lee, Sang Myeong" sort="Lee, Sang Myeong" uniqKey="Lee S" first="Sang-Myeong" last="Lee">Sang-Myeong Lee</name><name sortKey="Nam, Jae Hwan" sort="Nam, Jae Hwan" uniqKey="Nam J" first="Jae-Hwan" last="Nam">Jae-Hwan Nam</name><name sortKey="Park, Hye Lim" sort="Park, Hye Lim" uniqKey="Park H" first="Hye-Lim" last="Park">Hye-Lim Park</name><name sortKey="Seo, Dong Won" sort="Seo, Dong Won" uniqKey="Seo D" first="Dong-Won" last="Seo">Dong-Won Seo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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